CVE-2025-68463 json
Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez
published 2025-12-18 10 mo ago modified 2026-10-13 26 d ago also GHSA-x3vf-39hj-gxr4 , PYSEC-2026-1221 , EUVD-2025-204037
- cvss
- 4.9
- version 3.1, CNA
- cisa kev
- Not listed
- not in CISA's catalog
- epss
- 0.3%
- EPSS 0.3% chance of exploitation in 30 days, percentile 24%
- public exploits
- 0
- none known
Summary
Bio.Entrez in Biopython through 186 allows doctype XXE.
Patch / fix
- pypi biopython 1.87
- python-biopython Debian 14 1.87+dfsg-1
debian advisories DEBIAN-CVE-2025-68463
- python-biopython openSUSE Leap 16.0 1.85-bp160.2.1
- python-biopython openSUSE Tumbleweed 1.87-1.1
opensuse advisories openSUSE-SU-2026:21169-1openSUSE-SU-2026:10537-1
Vendor advisories
What the vendors themselves say about their products: affected, fixed or not affected, and what to do.
red hat product security vex CVE-2025-68463 updated cvss 7.1
python-biopython: python-biopython: Information disclosure via XML External Entity (XXE) vulnerability in Bio.Entrez
-
Red Hat All currently supported Red Hat productsnot affected: vulnerable code not present
Red Hat CSAF VEX © Red Hat, Inc., from https://security.access.redhat.com/data/csaf/v2/vex/; changed: reduced to product statuses and remediations. CC BY 4.0 · csaf
CISA SSVC
- Exploitation
- none
- Automatable
- no
- Technical impact
- partial
- Assessed
- 10 mo ago
Exploit prediction
0.32% chance of exploitation in the next 30 days, higher than 24% of all scored CVEs (FIRST EPSS, 2026-11-08).
CVSS scores
| assigned by | version | score | vector |
|---|---|---|---|
| CNA | 3.1 | 4.9 | CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L |
| GitHub | 3.1 | 4.9 | CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L |
| OSV | 3.1 | 4.9 | CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L |
Affected packages
| ecosystem | package | affected | fixed in |
|---|---|---|---|
| pypi | biopython | <=1.86 <1.87 |
1.87 |
Affected products
- Biopython Biopython
Classification
- Weakness
-
- CWE-611 Improper Restriction of XML External Entity Reference
References
-
github.com
/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d
web
-
github.com
/biopython/biopython/issues/5109
web
- pypi.org /project/biopython/1.87/
-
github.com
/biopython/biopython/blob/master/NEWS.rst
web
-
openwall.com
/lists/oss-security/2026/05/08/16
web
-
nvd.nist.gov
/vuln/detail/CVE-2025-68463
advisory
-
github.com
/biopython/biopython
web
-
pypi.org
/project/biopython/1.87
web
-
pypi.org
/project/biopython
package
-
github.com
/advisories/GHSA-x3vf-39hj-gxr4
advisory
Sources
- CVE List CVE-2025-68463
- GitHub Advisory GHSA-x3vf-39hj-gxr4
- NVD CVE-2025-68463
- OSV PYSEC-2026-1221
Fencer Vulns keeps one entry per vulnerability: the CVE id wins, then GHSA, and records that alias each other are merged, except that two CVEs always keep separate entries. The same data is available as JSON.